The default save folder might be in a restricted location. Most emulators let you change the save path.

Aggressive antivirus software often mistakes emulator save states for ransomware behavior because the emulator writes large chunks of binary data quickly.

After adding exclusions, restart your PC and test the save.

Permission issues can be bypassed by elevating privileges:

If the error disappears, you have a permanent permissions problem. The better fix is to move your ROMs and saves to a non-protected folder (e.g., C:\Users\YourName\Emulation\).