Mmsmazacomin Better Direct

Mmsmazacomin-Better was synthesized via a multi-step reaction involving the acylation of the parent MMZ compound with a tert-butyl ester moiety. The structural integrity of the resulting crystalline solid was confirmed using Nuclear Magnetic Resonance (NMR) spectroscopy and High-Resolution Mass Spectrometry (HRMS).

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A cohort of 48 healthy male Wistar rats was divided into two groups ($n=24$ per group). Group A received an oral dose of standard Mmsmazacomin (10 mg/kg), while Group B received Mmsmazacomin-Better (10 mg/kg). Blood samples were collected at 0.5, 1, 2, 4, 8, 12, and 24 hours post-administration. Plasma concentrations were quantified to determine the Area Under the Curve (AUC), maximum concentration ($C_max$), and time to maximum concentration ($T_max$). Group A received an oral dose of standard