Wilcom E42 is a 32-bit application. It runs on 64-bit Windows 10 via WoW64 (Windows on Windows 64), but you must install it in the Program Files (x86) folder (automatic). Check your Windows version:

Solution:

Once the software launches successfully:

New Windows 10 installations do not have .NET 3.5 enabled by default.
Method:

How To Install Wilcom E42 In Windows 10 New Here

Wilcom E42 is a 32-bit application. It runs on 64-bit Windows 10 via WoW64 (Windows on Windows 64), but you must install it in the Program Files (x86) folder (automatic). Check your Windows version:

Solution:

Once the software launches successfully: how to install wilcom e42 in windows 10 new

New Windows 10 installations do not have .NET 3.5 enabled by default.
Method: Wilcom E42 is a 32-bit application