Gvg-526 Mother-to-child Adolescence Hatano Yui %7cverified%7c

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The sub‑study honors Dr. Yui Hatano, a pioneering perinatal epigeneticist whose early work linked maternal cortisol rhythms to offspring brain plasticity. In 2023, Dr. Hatano joined the GVG‑526 steering committee and spearheaded a focused arm of the project that zeroes in on adolescent psychosocial resilience. [List any sources cited in the paper, following

| Domain | Measured Variables | |--------|--------------------| | Neuroendocrine | Maternal cortisol AUC (area under curve) during each trimester; adolescent HPA‑axis reactivity at ages 12 & 16 | | Microbiome Transfer | Maternal gut‑vaginal microbiome composition at delivery; child gut microbiota at 6 months, 2 years, and 5 years | | Nutrition & Metabolism | Maternal macro‑ and micronutrient intake; child BMI trajectories; adolescent insulin sensitivity | | Psychosocial Environment | Maternal perceived stress (PSS‑10), social support indices, home‑environment quality scores | | Adolescent Outcomes | Emotional regulation (BRIEF‑2), risk‑taking behavior (BART), academic achievement (standardized test scores) | child gut microbiota at 6 months